In 2005, BMW introduced the R1200RT. The design of this model was completely different from the R1150RT with a 15% boost in power, 20 kg (44 lb) weight saving, optional electronic suspension adjustment (ESA) and on-board computer. A low seat and/or a lowered suspension were available for shorter riders reducing seat height to a lowest level of 820 mm (32.3 in), although the lowered suspension eliminates the ESA option. The standard electrically operated windscreen was adjustable across a range of heights.

The servo powered ABS brakes on the 2005 and 2006 models were partially integrated such that the rear brake pedal only applies the rear brake while the front brake lever applies both brakes. For the 2007 model year, servo assist was removed from the partially integrated brakes. A new, more advanced and lighter ABS system was produced by Continental Teves, which also produced the optional Automatic Stability Control (ASC), in BMW’s traction control system for motorcycles.